强精煎对脾肾两虚兼湿热瘀阻型合并精子DNA损伤男性不育症的影响OA
Effect of Qiangjing Decoction on Male Infertility with Sperm DNA Damage of Spleen-Kidney Deficiency and Damp-Heat and Blood Stasis Pattern
目的 观察强精煎联合维生素E治疗脾肾两虚兼湿热瘀阻型合并精子DNA损伤男性不育症的临床疗效.方法 选取防城港市中医医院符合纳入标准的60例精子DNA碎片指数(DFI)升高的脾肾两虚兼湿热瘀阻型合并精子DNA损伤男性不育症患者,依据随机数字表随机分为对照组和治疗组,每组各30例.对照组给予维生素E口服治疗,治疗组给予维生素E联合强精煎口服治疗,两组疗程均为3个月.对比两组治疗前后精子DFI、精液常规参数及中医证候积分变化情况,并比较临床疗效.结果 治疗后两组患者DFI均显著下降(P<0.05),治疗组下降幅度明显大于对照组(P<0.05).与治疗前相比,治疗组精子浓度、前向运动率、总活力及正常形态率均明显提升(P<0.05),对照组精子总活力、正常形态率明显改善(P<0.05),且治疗组各项指标的改善程度均优于对照组(P<0.05).治疗组治疗后中医证候积分较治疗前明显下降(P<0.05),且低于对照组(P<0.05).治疗组临床总有效率90%(27/30),明显高于对照组63.3%(19/30)(P<0.05).结论 强精煎联合维生素E治疗脾肾两虚兼湿热瘀阻型合并精子DNA损伤的男性不育症,能够有效改善精子DNA完整性及精液质量,其临床疗效优于单纯抗氧化治疗.
Objective To observe the clinical efficacy of Qiangjing Decoction combined with vitamin E in the treatment of male infertility with sperm DNA damage of spleen-kidney deficiency and damp-heat and blood stasis pattern.Methods A total of 60 patients of male infertility with sperm DNA damage of spleen-kidney deficiency and damp-heat and blood stasis pattern who met the inclusion criteria,characterized by elevated sperm DNA fragmentation index(DFI),were recruited from the Fangchenggang Hospital of Traditional Chinese Medicine.Subsequently,they were randomly divided into a treatment group and a control group using random number table,with 30 cases in each group.The control group received oral vitamin E alone,while the treatment group received a combination of Qiangjing Decoction and vitamin E.Both groups were treated for a duration of 3 months.The changes of sperm DFI,semen routine parameters and traditional Chinese medicine(TCM)syndrome scores,as well as the clinical efficacy,were compared between the two groups before and after treatment.Results After treatment,the DFI of the two groups decreased significantly(P<0.05),and the decrease in the treatment group was significantly greater than that in the control group(P<0.05).Compared with pre-treatment,the sperm concentration,progressive motility,total motility,and normal morphology rate in the treatment group were significantly increased(P<0.05);the total motility and normal morphology rate in the control group improved significantly(P<0.05).The improvement of each index in the treatment group was superior to the control group(P<0.05).The TCM syndrome scores in the treatment group were significantly reduced after treatment compared to baseline(P<0.05)and were significantly lower than those in the control group(P<0.05).Regarding clinical efficacy,the treatment group demonstrated a significantly higher total effective rate of 90%(27/30)compared to 63.3%(19/30)in the control group(P<0.05).Conclusion Qiangjing Decoction combined with vitamin E in the treatment of male infertility with sperm DNA damage of spleen-kidney deficiency and damp-heat and blood stasis pattern can effectively improve sperm DNA integrity and semen quality,and its clinical efficacy is better than that of simple antioxidant therapy.
王中;梁志迎;钱志香;宾彬;陆海旺;韩志林;王德胜
防城港市中医医院,广西 防城港 538000防城港市中医医院,广西 防城港 538000防城港市中医医院,广西 防城港 538000广西中医药大学第一附属医院,广西 南宁 530023广西中医药大学第一附属医院,广西 南宁 530023广西中医药大学第一附属医院,广西 南宁 530023广西中医药大学第二附属医院,广西 南宁 530011
强精煎男性不育症维生素E精子DNA碎片指数
Qiangjing DecoctionMale infertilityVitamin ESperm DNA fragmentation index
《中医药信息》 2026 (9)
54-57,63,5
国家自然科学基金项目(82160904)广西中医药适宜技术开发与推广项目(GZSY2024091)
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