7种中药注射液联合恩替卡韦对慢性乙型肝炎患者肝功能及肝纤维化水平影响的网状Meta分析OA

Objective:This study aims to evaluate the efficacy of Chinese herbal injections combined with entecavir in the treatment of chronic hepatitis B(CHB)based on network meta-analysis.Methods:The randomized controlled tri-als(RCTs)on the combined use of Chinese herbal injections and entecavir in the treatment of CHB were retrieved from Wanfang Data,VIP,CNKI,SinoMed,Cochrane Library,EMbase,PubMed,and Web of Science with the time interval from inception to October 28,2024.The Cochrane risk-of-bias tool was used for quality assessment of the included articles.RevMan 5.4 and Stata 17 were used for data analysis.Results:A total of 45 RCTs involving 4 165 patients were includ-ed,with seven Chinese herbal injections[Danshen(丹参)Injection,Kanglaite(康莱特)Injection,Kushenin Injection,Shuganning(舒肝宁)Injection,Danhong(丹红)Injection,Sophocarpidine Injection,and Kang'ai(康艾)Injection)]studied.The network meta-analysis revealed that the interventions that topped the cumulative probability rankings for each outcome were as follows:① Kushenin Injection combined with entecavir for reducing aspartate aminotransferase;②Kang'ai Injection combined with entecavir for reducing alanine aminotransferase;③ Danshen Injection combined with entecavir for reducing total bilirubin(TBIL);④ Danhong Injection combined with entecavir for reducing hyaluronic acid;⑤ Kushenin Injection combined with entecavir for reducing laminin;⑥ Kushenin Injection for reducing type Ⅳ collagen(Ⅳ-C);⑦ Danhong Injection combined with entecavir for reducing type Ⅲ procollagen N-terminal peptide(P-Ⅲ);⑧ Danshen Injection combined with entecavir for improving the total response rate.Conclusion:The current evidence suggests that the combinations of Chinese herbal injections with entecavir may enhance the therapeutic effects on CHB.However,due to the limitations in sample size and quality of included studies,large-scale and high-quality studies remain to be carried out to confirm these findings.