戒烟干预联合布地格福吸入气雾剂治疗稳定期慢性阻塞性肺疾病患者的临床研究OA

Objective:To assess whether adding a structured smoking-cessation program to budesonide/glycopyrronium/formoterol fumarate inhalation aerosol improves pulmonary function,systemic and airway inflammation,cellular immunity,and health-related quality of life in patients with stable chronic obstructive pulmonary disease(COPD).Method:Eighty-two patients with stable COPD treated at the Sixth People's Hospital of Kunshan between February 2023 and March 2024 were randomly assigned in a 1:1 ratio to a medication-only group or an intervention group,with 41 patients in each group.Both groups received standardized treatment with budesonide/glycopyrronium/formoterol fumarate inhalation aerosol,whereas the intervention group additionally participated in a 12-month structured smoking-cessation program.Pulmonary function,inflammatory biomarkers,immune indices,symptom burden,and quality of life were evaluated at baseline and after 3,6,and 12 months of follow-up.Result:Significant time effects and group-by-time interactions were identified for forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),FEV1/FVC,COPD Assessment Test scores,St George's Respiratory Questionnaire total scores,C-reactive protein,interleukin-6,fractional exhaled nitric oxide,CD3+,CD4+,CD8+,and the CD4+/CD8+ratio.Significant between-group effects were also observed for symptom and quality-of-life scores,inflammatory markers,and immune-cell indices.During the 12-month follow-up,acute exacerbations occurred less frequently in the intervention group than in the medication-only group.The above differences were all statistically significant(P<0.05).The overall incidences of throat discomfort,hoarseness,dry cough,and other treatment-related adverse events were comparable between groups(P>0.05).Conclusion:Incorporating structured smoking-cessation management into fixed-dose triple inhalation therapy provides additional clinical benefits for patients with stable COPD.Improvements in respiratory function,inflammatory status,cellular immunity,and health-related quality of life became more evident after 6 months and were sustained or further enhanced at 12 months,suggesting a cumulative benefit associated with prolonged smoking abstinence.This combined strategy may also reduce acute exacerbations without increasing adverse events.