耳鸣与焦虑症的共病遗传基因研究OA
A genetic study of comorbidity between tinnitus and anxiety disorders
目的 耳鸣与焦虑症存在临床联系,但遗传相关性尚不明确,本研究旨在探索耳鸣与焦虑的遗传关联以及共享的遗传结构.方法 使用两个大型全基因组关联研究数据进行一系列遗传分析.连锁不平衡评分回归用来计算遗传相关系数,全基因组关联研究的多性状分析和跨表型关联分析识别跨性状的共享遗传变异,基因注释多标记富集分析法和遗传功能注释完成基因注释.结果 本研究确定了耳鸣和焦虑症之间的正向遗传相关,识别了14个共享遗传变异(其中10个为候选因果变异)和6个重要的共享候选基因.结论 耳鸣和焦虑症之间存在正向遗传关联,并共享遗传变异和基因.
Objective Tinnitus and anxiety are clinically associated,but their genetic correlation remains unclear.This study aims to explore genetic associations between tinnitus and anxiety and identify shared genetic architecture.Methods A series of genetic analyses were conducted using data from two large genome-wide association studies(GWAS).Linkage disequilibrium score regression was used to calculate genetic correlations,while multi-trait analysis of GWAS and cross-phenotype association analysis were employed to identify cross-trait shared genetic variants.Gene annotation was performed using multi-marker analysis of GenoMic Annotation and Annotation of genetic Variants(ANNOVAR).Results A positive genetic correlation between tinnitus and anxiety was identified,with 14 shared genetic variants(including 10 causal variants)and 6 prioritized shared genes.Conclusions A positive genetic correlation exists between tinnitus and anxiety,and both conditions share certain genetic variants and loci.
郭珍;刘奕彤;林勇
成都市郫都区中医医院耳鼻喉科,成都 611730成都市郫都区中医医院耳鼻喉科,成都 611730成都市郫都区中医医院耳鼻喉科,成都 611730
耳鸣焦虑症遗传关联遗传结构
tinnitusanxietygenetic associationgenetic structure
《中华耳科学杂志》 2026 (9)
850-854,5
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