薏苡仁调控肠-肌肉轴干预类风湿肌少症的作用机制OA

Sarcopenia,a common complication of rheumatoid arthritis(RA),significantly elevates risks of joint dysfunction,falls,fractures,and mortality in RA patients,severely impairing overall health status,quality of life,and long-term prognosis.This review examines advancements in treating RA-associated sarcopenia with Yiyiren through the gut-microbiota-muscle relationship.In traditional Chinese medicine,RA-sarcopenia is classified within flaccidity syndrome,consumptive disease,and muscular atrophy categories.Anchored in traditional Chinese medicine theories that"the spleen governs transportation and transformation"and"the spleen associates with muscles",therapeutic strategies targeting the spleen align with the modern gut-muscle axis concept.Yiyiren,recognized for fortifying the spleen,resolving dampness,and alleviating arthralgia,modulates gut dysbiosis and enhances beneficial fatty acid production.These actions suppress inflammation,enhance mitochondrial function,regulate intramuscular lipid metabolism,and reduce insulin resistance.This multi-target,multi-level regulatory mechanism underscores its potential for preventing and treating RA-sarcopenia.