非小细胞肺癌脑转移中肿瘤细胞与脑微环境互作机制研究进展OA

Brain metastasis in non-small cell lung cancer(NSCLC)is shaped by continuous interactions between tumor cells and the brain-specific microenvironment.Vascular,glial and immune components contribute to intracranial colo-nization,immune escape and therapeutic resistance,while single-cell and spatial omics reveal heterogeneity in cellular states,communication networks and spatial niches.This review summarizes NSCLC brain metastasis and intracranial colonization,the brain metastatic microenvironment and tumor-microenvironment interactions,and discusses the heterogeneity revealed by single-cell and spatial omics and its potential relevance to therapeutic response and patient stratification.