三叉神经自主神经性头痛的临床诊治及机制研究进展OA

Trigeminal autonomic cephalalgias(TACs)are a group of primary headache syndromes characterized by unilateral headache and ipsilateral craniofacial autonomic symptoms.TACs include cluster headache,paroxysmal hemi-crania,short-lasting unilateral neuralgiform headache attacks(including short-lasting unilateral neuralgiform headache at-tacks with conjunctival injection and tearing and short-lasting unilateral neuralgiform headache attacks with craniofacial au-tonomic symptoms),and hemicrania continua.The pathophysiology involves the trigeminovascular system,the autonomic nervous system,the hypothalamus,and the recently identified role of the vagus nerve.Diagnosis mainly relies on head-ache attack frequency,duration,and accompanying symptoms.Each TAC has its unique clinical manifestations,patho-physiology,and treatment methods,which are discussed in depth in this review.