降钙素基因相关肽在丛集性头痛发病机制及鉴别诊断中的研究进展OA

Cluster headache(CH)is a severe primary headache disorder characterized by excruciating pain,with a complex pathophysiology involving intricate interactions among the trigeminovascular system,the hypothalamic circadian clock,and the autonomic nervous system.In recent years,calcitonin gene-related peptide(CGRP),recognized as a core mediator in migraine pathophysiology,has also attracted substantial attention regarding its role in CH.This review aims to thoroughly dissect the central role of CGRP in the pathogenesis of CH,systematically elaborate on the relationship between the circadian rhythmicity of CH attacks and the regulation of CGRP pathways,and,through differential diagnostic analysis of CH versus other trigeminal autonomic cephalalgias,reveal the distinct roles of CGRP pathways across different head-ache subtypes.By integrating the latest preclinical studies,clinical trial data,and biomarker explorations,this article seeks to provide a comprehensive reference for understanding the complex pathophysiology of CH and for developing novel targeted therapeutic strategies.