前庭性偏头痛相关认知功能障碍的研究进展OA

Vestibular migraine(VM)is not only a common cause of episodic vertigo but also a systemic disorder in-volving extensive brain network dysfunction.In addition to typical headache and severe vestibular symptoms,VM is often accompanied by significant cognitive alterations that seriously impair the daily functioning and social capacity of patients.This article systematically reviews the latest research advances in VM-associated cognitive impairment in terms of clinical phenotypes,potential pathophysiological mechanisms,biomarkers,and assessment scales.Clinical assessments show that VM-associated cognitive impairment mainly manifests as retardation of thinking,impaired attention and working memory,increased cognitive load,and impaired executive function,as well as a potential increase in the risk of falls.Neuroimaging and neuroelectrophysiological evidence has revealed the presence of microstructural damage along with mac-roscopic functional network reorganization and structural alterations in the brains of VM patients.Besides,5-hydroxytryp-tamine,calcitonin gene-related peptide,macrophage migration inhibitory factor,and 25-OH vitamin D may participate in the development and progression of VM-associated cognitive impairment.In conclusion,through a comprehensive assess-ment of scales,neuroimaging,electrophysiological examination,and serological biomarkers,cognitive screening in VM patients can achieve early detection of cognitive dysfunction,and effective interventions should be performed to control the symptoms of VM while protecting cognitive function,so as to improve long-term prognosis and quality of life for these pa-tients.