金属基纳米材料在卵巢癌诊疗中的研究进展OA

Ovarian cancer is the most lethal malignant tumor of the female reproductive system.This disease has insidious early symptoms and lacks effective screening methods,so most patients are diagnosed at advanced stages,resulting in a high recurrence rate after surgery and an extremely poor overall prognosis.Benefiting from their favorable properties including excellent biocompatibility,tunable surface functionalization,and multimodal imaging capacity,metal-based nanomaterials exhibit tremendous application potential in the early diagnosis,precise treatment,and therapeutic response surveillance of ovarian cancer.This review systematically categorizes and characterizes various metal-based nanomaterials,elaborates on their core mechanisms underlying tumor microenvironment responsiveness,antitumor biological effects,multimodal imaging signal amplification,and synergistic theranostic integration,and comprehensively discusses their research progress across the full-cycle clinical management of ovarian cancer,including early screening,preoperative precise imaging,intraoperative navigation resection,and postoperative dynamic monitoring.Collectively,this work delivers innovative strategies for the diagnosis and treatment of ovarian cancer.Meanwhile,this paper conducts hierarchical analysis targeting the core pathological challenge of characteristic extensive peritoneal dissemination in ovarian cancer,and constructs a systematic sorting framework centered on clinical diagnosis and treatment demands.