超声促细胞膜渗透机制:关于分子动力学的模拟现状OA

Cell membranes can regulate the entry and exit of substances into and out of cells,and ultrasound can have a non-invasive technical means at the cell level,which has been widely studied.In-depth research on the mechanism of action of ultrasound on cell membrane structure will help to assist in the design of liposome drugs and better achieve targeted drug delivery.This study will focus on exploring two ways in which ultrasound affects cell membranes,and use molecular dynamics simulation technology to explain how ultrasound affects the permeability of cell membranes.The shock wave model is suitable for studying the transient effects of ultrasonic cavitation,studying the shock wave generated by the rupture of cavitation bubbles and the destruction behavior of the jet on the membrane,and reproducing this dynamic process.The ultrasonic vibration model is suitable for studying the entire process of the action of ultrasound on the membrane structure,and studying the changes of the membrane's morphological characteristics under the condition of alternating positive and negative pressures.In addition,this paper also points out shortcomings in current research.Future research needs to further explore the impact of ultrasound on different cell membrane types and optimize ultrasound parameters to achieve more precise treatment.