红细胞分布宽度与白蛋白比值、同型半胱氨酸、C反应蛋白与老年共病患者继发衰弱的相关性OA
Correlation between red blood cell distribution width/albumin ratio,homocysteine,C-reactive protein and secondary frailty in older patients with comorbidities
目的 探讨红细胞分布宽度(RDW)/白蛋白(ALB)、同型半胱氨酸(Hcy)、C反应蛋白(CRP)与老年共病患者肌少症综合干预后继发衰弱的相关性,及三者联合应用对综合干预后继发衰弱情况的预测价值.方法 前瞻性选取2024 年1 月至2025 年5 月昆明市第二人民医院收治的老年共病住院肌少症患者120 例,依据综合干预后继发衰弱情况,将患者分别纳入衰弱组(n=34)和非衰弱组(n=86).比较2 组患者基线资料并采用倾向评分匹配降低组间偏倚后,比较2 组RDW/ALB、H cy、CRP,探究各指标对老年共病患者肌少症综合干预后继发衰弱的影响,分析RDW/ALB、Hcy、CRP单独及联合检测对老年共病患者肌少症综合干预后继发衰弱的预测价值.结果 衰弱组患者RDW/ALB、Hcy、CRP水平高于非衰弱组(P＜0.05).RDW/ALB、Hcy、CRP升高均是老年共病患者肌少症综合干预后继发衰弱的独立相关影响因素(P＜0.05).RDW/ALB、Hcy、CRP单独预测时,RDW/ALB的曲线下面积(AUC)值最大,CRP的敏感度最高,Hcy的特异度最高(P＜0.05),CRP+RDW/ALB+Hcy联合预测AUC值高于各指标单独预测(P＜0.05).结论 RDW/ALB、Hcy、CRP与老年共病患者肌少症综合干预后继发衰弱有关,联合检测可为临床预测继发衰弱情况提供参考.
Objective To explore the correlation between red blood cell distribution width(RDW)/albumin(ALB),homocysteine(Hcy),C reactive protein(CRP)and secondary frailty after comprehensive intervention for sarcopenia in older patients with comorbidities,and evaluatethe predictive value of their combined application for secondary frailty after comprehensive intervention.Methods A total of 120 older patients with comorbidities and sarcopenia admitted to the Second People's Hospital of Kunming from January 2024 to May 2025 were prospectively selected.Based on the occurrence of secondary frailty after comprehensive intervention,they were divided into frail group(34 cases)and non-frail group(86 cases).The baseline data of the two groups were compared.The propensity score matching was applied to reduce intergroup bias.The levels of RDW/ALB,Hcy and CRP were compared between the two groups.The effects of these indicators on secondary frailty in older patients with comorbidities after comprehensive intervention for sarcopenia was analyzed,and their individual and combined predictive values for secondary frailty in older patients with comorbidities after comprehensive intervention for sarcopenia was analyzed.Results The levels of RDW/ALB,Hcy and CRP in the frail group were higher than those in the non-frail group(P＜0.05).Elevated levels of RDW/ALB,Hcy and CRP were independently associated with secondary frailty after comprehensive intervention for sarcopenia in older patients with comorbidities(P＜0.05).In individual prediction,RDW/ALB showed the largest area under the curve(AUC),CRP had the highest sensitivity,and Hcy demonstrated the highest specificity(P＜0.05).The combined prediction AUC value of CRP+RDW/ALB+Hcy was significantly higher than that of each individual indicator.Conclusion RDW/ALB,Hcy and CRP are associated with the development of secondary frailty after comprehensive intervention for sarcopenia in older patients with comorbidities.Their combined detectioncan provide a valuable reference for the clinical prediction of secondary frailty.
李海欣;马继娟;吴红宝;梁碧娟;苏建培;顾俊;王志敏;李瑞乾;陈玉兰;杨磊;闻丽芬;代林玲
昆明市第二人民医院骨科,云南 昆明 650000昆明市第二人民医院老年病科,云南 昆明 650000昆明市第二人民医院老年病科,云南 昆明 650000昆明市第二人民医院老年病科,云南 昆明 650000昆明市第二人民医院老年病科,云南 昆明 650000昆明市第二人民医院老年病科,云南 昆明 650000昆明市第二人民医院老年病科,云南 昆明 650000北京大学肿瘤医院云南医院/云南省肿瘤医院老年科,云南 昆明 650118昆明市第二人民医院心内科,云南 昆明 650000昆明市第二人民医院康复科,云南 昆明 650000昆明市第二人民医院老年病科,云南 昆明 650000昆明市第二人民医院老年病科,云南 昆明 650000
老年人共病肌少症衰弱红细胞分布宽度与白蛋白比值同型半胱氨酸C反应蛋白
older adultscomorbiditysarcopeniafrailtyred cell volume distribution width/albumin ratiohomocysteineC-reactive protein
《老年医学与保健》 2026 (4)
545-550,6
昆明市科技计划项目(2024-1-NS-029,2025-NS-018)昆明市卫生科技人才培养项目医学科技学科带头人培养计划[2025-SW(带头)-38]昆明市卫生健康委员会卫生科研课题项目(2025-03-10-001)
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