抗氧化类益生菌延缓雌性动物卵巢衰老的作用机制与研究进展OA

Ovarian aging can lead to decreased fertility,endocrine disorders,and impaired systemic health in female animals.Its pathogenesis is closely associated with oxidative stress,immune inflammation,gut microbi-ota dysbiosis and hypothalamic-pituitary-ovarian axis dysfunction.Antioxidant probiotics,owing to their antiox-idative,anti-inflammatory,and immunomodulatory properties,have become a frontier hotspot for research on delaying ovarian aging.These probiotics can alleviate ovarian inflammation by modulating gut homeostasis,re-pairing the intestinal barrier and reducing the entry of endotoxins into the bloodstream.Simultaneously,they regulate the levels of metabolites such as short-chain fatty acids,scavenge reactive oxygen species,and activate the endogenous antioxidant defense system.Furthermore,they inhibit granulosa cell apoptosis,preserve follicu-lar reserve and improve ovarian function through multiple pathways.This review outlined the core mechanisms of ovarian aging and elaborated on the pathways through which antioxidant probiotics delay ovarian aging in fe-male animals,aiming to provide a reference for related research and applications.