鹿茸的生物学特性及视黄酸信号通路在鹿茸生长中的调控机制研究进展OA

Antler is an important economic trait of sika deer,and its yield and quality are directly related to the economic benefits.The rapid regeneration and growth of antler mainly depend on the proliferation and differen-tiation of cells in the growth center.Among these processes,the chondrogenic differentiation of antler mesen-chymal stem cells(AnSCs)serves as an important cellular basis for antler tissue formation and growth and re-presents a key biological process affecting antler yield.Retinoic acid(RA)is the active metabolite of vitamin A,RA signaling pathway has attracted increasing attention for its role in regulating the fate of AnSCs.This re-view focuses on cellular differentiation and regulatory mechanisms involved in antler growth,systematically summarizes the composition and functions of the RA signaling pathway,and discusses its potential roles in An-SC differentiation and antler growth,aiming to provide a reference for vitamin A nutritional regulation in sika deer during the antler growth period and for improving antler yield.