母体三碘甲状腺原氨酸调控胎儿棕色脂肪组织发育的研究进展OA

Brown adipose tissue plays a crucial role in maintaining the body temperature and energy metabolism of young animals through its unique thermogenic function.The development of fetal brown adipose tissue dur-ing the embryonic stage is closely related to the maternal active thyroid hormone triiodothyronine(T3).Mater-nal T3 enters the fetus through the placental transport system and thereby affects the development of fetal brown adipose tissue during pregnancy.T3 promotes the proliferation and directed differentiation of brown adipose pro-genitor cells by binding to thyroid hormone receptors,thereby regulating brown adipose tissue development and controlling mitochondrial biogenesis and homeostasis through genomic and non-genomic pathways,ensuring the thermogenic basis.This article reviews the core role and molecular mechanism of maternal T3 entering the fetus through the placental transport system and influencing the development of fetal brown adipose tissue during the later stages of pregnancy,revealing the developmental rules of fetal brown adipose tissue,and providing an im-portant theoretical basis for nutritional regulation during the later stages of pregnancy in female animals and ear-ly health management of newborn animals.