基于脑络"体-用"失衡的老年脑小血管病病机演变规律OA

Cerebral small vessel disease(CSVD)is a heterogeneous condition affecting small vessels in the brain and is closely associated with cognitive dysfunction,gait abnormalities,and emotional disorder in the elderly.Based on the collateral disease theory of traditional Chinese medicine(TCM),a"form-function"pathogenesis frame-work for elderly CSVD is proposed from the perspective of their relationship.In this framework,the"form"refers to the morphological basis of the brain collaterals and sweat pore,while the"function"refers to the activities of qi-blood circulation,nourishment and regulation,as well as the body fluid transportation and distribution;the two are interde-pendent and jointly maintain the mental activities of the brain.Under this framework,the dynamic pathogenesis evolu-tion patterns of CSVD,namely collateral fragility,collateral rigidity,collateral stagnation,and collateral damage,are systematically explained,revealing the potential mechanisms underlying the transformation of age-related physio-logical decline of brain collaterals into pathological impairment.This provides a theoretical foundation for the diagno-sis and treatment of elderly CSVD with TCM.