活血解毒类中药调控核因子κB抗动脉粥样硬化机制的研究进展OA
Research Progress on the Anti-atherosclerosis Mechanisms of Blood-activating and Detoxifying Traditional Chinese Medicines by Regulating NF-κB Pathway
核因子κB(nuclear factor κB,NF-κB)信号通路通过介导内皮细胞损伤、调控巨噬细胞极化与铁死亡、调控血管平滑肌细胞与斑块稳定性延缓动脉粥样硬化(atherosclerosis,AS)的发生发展.中医学认为,瘀毒互为因果,相互胶结,贯穿 AS的发生发展的全过程.基于 AS的中医病因病机,活血解毒法已成为中医药治疗该病的重要治法之一.从中药活性成分和中药复方两个层面,系统梳理活血解毒类中药调控NF-κB信号通路抗AS的研究进展,明确该通路是此类中药防治 AS的关键靶点.
The nuclear factor κB(NF-κB)signaling pathway delays the occurrence and development of atherosclerosis(AS)by mediating endothelial cell injury,regulating macrophage polarization,ferroptosis,and regulating the stability of vascular smooth muscle cells and plaques.According to Traditional Chinese Medicine theories,blood stasis and toxins are mutually causal and interdependent factors,running through the occurrence and the entire process of AS.Based on the etiology and pathogenesis of AS,the method of promoting blood circulation and detoxification has become one of the important therapeutic approaches for AS.This paper systematically reviews the research progress on the active ingredients and compound prescriptions of blood-activating and detoxifying Traditional Chinese Medicines against AS by regulating NF-κB signaling pathway.It is suggested that the NF-κB pathway may be the key target of blood-activating and detoxifying Traditional Chinese Medicines for the prevention and treatment of AS.
师文琪;何鑫;刘国飞;司春婴;陈恒
河南中医药大学第一临床医学院(中西医结合学院),河南 郑州 450000河南中医药大学第一临床医学院(中西医结合学院),河南 郑州 450000河南中医药大学第一临床医学院(中西医结合学院),河南 郑州 450000河南中医药大学第一附属医院,河南 郑州 450000河南中医药大学第一附属医院,河南 郑州 450000
医药卫生
动脉粥样硬化NF-κB信号通路病机病机中药活血解毒作用机制
atherosclerosisNF-κB signaling pathwayetiology and pathogenesisTraditional Chinese Medicinepromotion of blood circulation and detoxicationmechanism
《中医研究》 2026 (8)
86-91,6
河南省医学科技攻关计划联合共建项目(LHGJ20240669)河南省卫生健康委员会国家中医药传承创新中心联合共建科研专项课题(2024ZXZX1067)2023 年河南省本科高校大学生创新创业训练计划省级立项项目(202310471019)
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