绵羊肺腺瘤病病原学和流行病学研究进展OA
Research Progress on the Etiology and Epidemiology of Ovine Pulmonary Adenomatosis
绵羊肺腺瘤病(OPA)是由绵羊肺腺瘤病毒(JSRV)感染引起的绵羊高度致死性、传染性肿瘤疾病,给全球养羊业造成了严重的经济损失.然而,目前OPA和JSRV的研究较分散.JSRV基因组编码的囊膜(Env)蛋白是主要致病因素,与Hyal2受体结合诱导一系列信号通路转导,成为主要致病机制.本文系统综述了JRSV病原学特征、OPA发病机制及其流行病学防治,并从新型疫苗的研发、人工智能技术的应用和基因编辑的应用3个方面展望了未来研究方向,以期为OPA防控措施的制订提供依据.
Ovine pulmonary adenocarcinoma(OPA)is a highly fatal and contagious neoplastic disease in sheep caused by infection with jaagsiekte sheep retrovirus(JSRV),resulting in severe economic losses to the global sheep industry.However,current studies on OPA and JSRV remain relatively fragmented.The envelope(Env)protein encoded by the JSRV genome is considered the major pathogenic factor.By binding to the Hyal2 receptor,Env induces a series of signaling pathways and thereby mediates the principal pathogenic mechanisms.This review systematically summarizes the etiological characteristics of JSRV,the pathogenesis of OPA,and its epidemiology and prevention strategies.In addition,future research directions are discussed from three aspects,including the development of novel vaccines,the application of artificial intelligence technologies,and the use of gene-editing approaches,with the aim of providing a theoretical basis for the prevention and control of OPA.
王雨林;陈政翰;石书骏;朱丽娜;张瑞;安雪姣;施海娜;岳耀敬
中国农业科学院兰州畜牧与兽药研究所,甘肃 兰州 730050中国农业科学院兰州畜牧与兽药研究所,甘肃 兰州 730050中国农业科学院兰州畜牧与兽药研究所,甘肃 兰州 730050中国农业科学院兰州畜牧与兽药研究所,甘肃 兰州 730050中国农业科学院兰州畜牧与兽药研究所,甘肃 兰州 730050中国农业科学院兰州畜牧与兽药研究所,甘肃 兰州 730050庆阳市农业科学院,甘肃 庆阳 745000中国农业科学院兰州畜牧与兽药研究所,甘肃 兰州 730050
农业科技
绵羊肺腺瘤病(OPA)绵羊肺腺瘤病毒(JSRV)抗病毒药物疫苗防控
ovine pulmonary adenomatosis(OPA)jaagsiekte sheep retrovirus(JSRV)antiviral drugvaccineprevention and control
《中国兽医杂志》 2026 (8)
111-116,6
农业农村部科技创新2030农业生物育种重大项目(2022ZD040130209)
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