芽孢杆菌生物膜形成中群体感应信号分子的动态调控OA

Bacillus spp.are important biocontrol agents that suppress plant pathogens through ecological niche com-petition,antibacterial metabolites(such as lipopeptides and polyketides),and induced systemic resistance.Their biocontrol efficacy is correlated with biofilm formation capability.Biofilms,structured by extracellular polymeric sub-stances(EPS),enhance bacterial adhesion to plant surfaces and tolerance to environmental stress,thereby prolon-ging the duration of biocontrol.Recent studies revealed that biofilm formation of Bacillus spp.was regulated by the quorum sensing(QS)system.This system coordinated population behaviors through density-dependent signaling molecules(e.g.,lipopeptides,autoinducer-2,or acyl-homoserine lactones).The QS system not only influences the synthesis of extracellular polymeric substances by regulating key transcription factors such as degU and sinR,thereby affecting the structure and stability of biofilms,it also coordinates the secretion of related substances by microbial communities to promote plant growth,enhance environmental stress responses,and antagonize pathogenic bacteria.Current research on the QS system in Bacillus spp.still faces numerous challenges and limitations in genetic manipu-lation and microecology.Future studies can continue to develop suitable chromosomal integration expression systems,analyze in situ metabolism and interaction networks,and explore key regulatory genes to provide a theoretical basis for optimizing Bacillus spp.colonization capacity and improving their biocontrol efficiency.