DNA甲基化与m6A修饰在失眠中的协同调控作用与机制OA
DNA methylation and m6A RNA modification:synergistic regulatory roles and underlying mechanisms in insomnia
失眠是一种全球高发的睡眠障碍,其发病机制复杂,是遗传易感性、环境压力及心理生理等因素交互作用的结果.表观遗传学被认为是一种可能通过环境影响基因表达的分子机制,DNA甲基化和N6-甲基腺苷(m6A)修饰作为两类关键的表观遗传修饰,可将环境压力等因素转化为基因表达的持续性改变,是连接外在诱因与失眠内在易感性的分子桥梁.本文系统梳理DNA甲基化、m6A修饰与失眠关联的现有研究证据,探讨其通过调控昼夜节律及神经相关基因的表达,进而引发失眠的核心机制,证实失眠患者存在特定的表观遗传谱改变,并提出未来可依托多组学整合分析与纵向队列研究,推动失眠相关生物标志物的挖掘及表观遗传疗法的临床转化.
Insomnia is a sleep disorder with a high global incidence;its pathogenesis is complex,involving the interaction of genetic predisposition,environmental stress,and psychophysiological factors.Epigenetics is a molecular mechanism that affects gene expression through environmental interaction.DNA methylation and N6-methyladenosine(m6A)modification are epigenetic mechanisms triggered by environmental stress and other factors,resulting in lasting changes in gene expression;they are a molecular bridge connecting external triggers and intrinsic susceptibility to insomnia.This article aims to systematically consolidate the existing evidence on the association between DNA methylation and m6A modification and insomnia,explore the core mechanism of insomnia affecting the regulation of circadian rhythm and the expression of neurologically related genes,confirm specific epigenetic profile changes in patients with insomnia,and propose future research directions to promote the discovery of biomarkers and the translation of epigenetic therapies through multi-omics integration and longitudinal research.
周艳丽;陈瑶;刘京霞;高希言;郭娅静
河南中医药大学,郑州 450000河南中医药大学,郑州 450000河南中医药大学,郑州 450000河南中医药大学第三附属医院,郑州 450000河南中医药大学,郑州 450000
医药卫生
失眠DNA甲基化m6A修饰表观遗传学
insomniaDNA methylationm6A modificationepigenetics
《中国比较医学杂志》 2026 (15)
128-139,12
国家自然科学基金(82474655,82405585)河南省重点研发专项(251111311400)河南省科技攻关项目(252102311264)中国博士后科学基金(2025M773941).
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