养老机构居住者鼻前庭致病菌定植情况及其危险因素OA

Objective To investigate the status of nasal vestibule pathogenic bacteria colonization and related risk factors among residents in elderly care institutions.Methods Eligible residents from 4 elderly care institutions in Qidong were enrolled and divided into the pathogenic bacteria colonization group and the non-colonization group according to nasal vestibule pathogenic bacteria colonization test results.Nasal vestibule swab samples were collected for bacteria isolation,culture and identification.Relevant clinical and epidemiological data were collected.Univariate analysis and multivariate logistic regression analyses were used to identify independent risk factors for pathogenic bacteria colonization.Results Among 139 nasal vestibule samples,46(33.09%)tested positive for bacteria,of which 44 were positive for pathogenic bacteria,with a total of 50 pathogenic bacterial strains isolated.Klebsiella pneumoniae accounted for the highest proportion(35 strains,70.00%),and no multidrug-resistant bacteria were detected.Univariate analysis showed statistically significant differences between the colonization group and the non-colonization group in age,antibiotic use within the past 3 months,diabetes mellitus,and hygiene habits(all P<0.05).Multivariate logistic regression analysis revealed that advanced age(OR=1.045,95%CI:1.008-1.083),diabetes mellitus(OR=3.141,95%CI:1.123-8.787),antibiotic use within the past 3 months(OR=6.085,95%CI:1.359-27.257),and fair hygiene habits(OR=3.172,95%CI:1.155-8.710)were independent risk factors for nasal vestibule pathogenic bacteria colonization(all P<0.05).Conclusion The colonization rate of nasal vestibule pathogenic bacteria among residents in elderly care institutions is relatively high.Targeted prevention and control strategies focusing on advanced age,diabetes mellitus,recent antimicrobial exposure,and poor hygiene habits should be formulated to reduce the colonization rate and the risk of subsequent infection.