巨噬细胞线粒体功能障碍在急慢性肾脏疾病中的作用机制与治疗潜力OA
Mechanism and therapeutic potential of macrophage mitochondrial dys-function in acute and chronic kidney diseases
巨噬细胞线粒体功能障碍是驱动肾脏疾病发生发展的重要因素.在肾脏缺血、脓毒症和纤维化等病理状态下,多种因素的作用会导致巨噬细胞线粒体发生代谢功能紊乱、炎症因子释放、线粒体质量控制受损等变化,进而加重肾脏组织的损伤.本综述总结了巨噬细胞线粒体功能障碍在急性肾损伤、慢性肾脏病、糖尿病肾病三种常见肾脏疾病进展过程中的作用机制,同时阐述了线粒体靶向疗法在优化肾脏疾病的治疗、缓解肾损伤方面的潜力.
Macrophage mitochondrial dysfunction is an important factor driving the initiation and progression of kidney diseases.Under pathological conditions such as renal ischemia,sepsis,and fibrosis,multiple factors can in-duce metabolic disturbances,excessive inflammatory mediator release,and impaired mitochondrial quality control in mac-rophages,thereby aggravating renal tissue injury.This review summarizes the mechanisms by which macrophage mito-chondrial dysfunction contributes to the progression of three common kidney diseases,including acute kidney injury,chronic kidney disease,and diabetic kidney disease.In addition,it discusses the therapeutic potential of mitochondria-targeted interventions in optimizing the treatment of kidney diseases and alleviating renal injury.
孙海棚;杨敏;薛澄
青岛大学附属泰安市中心医院高新院区肾病科,山东 泰安 271000泰安八十八医院肾内科,山东 泰安 271000上海长征医院肾内科,解放军肾脏病研究所,海军军医大学第二附属医院,上海 200003
医药卫生
巨噬细胞线粒体功能障碍肾脏病治疗潜力
macrophagesmitochondrial dysfunctionkidney diseasestherapeutic potential
《中国病理生理杂志》 2026 (8)
1675-1680,6
上海市科技计划项目(No.24142201800)
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