内皮-间充质转化在心脏毒性中作用机制及干预策略的研究进展OA

Endothelial-mesenchymal transition(EndMT)is a process in which endothelial cells lose their en-dothelial characteristics and acquire mesenchymal features in response to external stimuli.While EndMT is essential for physiological cardiac development,aberrant EndMT is widely involved in the onset and progression of cardiovascular dis-eases.Cardiotoxicity refers to heart damage caused by toxic agents such as drugs,radiation,or viruses,and may result in serious cardiovascular conditions,including heart failure,cardiac fibrosis,and valvular heart disease.A growing body of research has demonstrated that EndMT plays a crucial regulatory role in the development of cardiotoxicity.This review summarizes the effects and molecular mechanisms by which exogenous toxic substances induce EndMT to cause cardio-toxicity.It also discusses therapeutic strategies targeting EndMT to alleviate cardiotoxicity and outlines future directions for research in this area,aiming to provide reference materials for the clinical management of cardiotoxicity.