鼻内镜下经泪前隐窝入路手术对上颌窦内翻性乳头状瘤患者炎性因子及并发症的影响OA

Objective To investigate the effect of endoscopic pre-lacrimal recess approach(PLRA)surgery in the treatment of maxillary sinus inverted papilloma(IP).Methods A total of 150 patients with maxillary sinus IP admitted to Sanming First Hospital Affiliated to Fujian Medical University from January 2021 to January 2026 were randomly divided into the control group and the observation group using a random number table method,with 75 cases in each group.The control group was treated with endoscopic middle and inferior meatal fenestration,while the observation group was treated with endoscopic PLRA surgery.Perioperative indicators,levels of inflammatory stress markers,nasal ventilation function,and complications were compared between the two groups.Results Compared with the control group,the observation group had less intraoperative blood loss,shorter operative time and hospital stay,and a lower total incidence of complications,with statistically significant difference(P<0.05);compared with the control group,the observation group had lower levels of interleukin-8(IL-8),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),cortisol(Cor),and epinephrine(E)on postoperative day 3,with statistically significant difference(P<0.05);compared with the control group,the observation group had larger nasal minimal cross-sectional area and nasal cavity volume,and samaller nasal resistance at 3 months postoperatively,with statistically significant difference(P<0.05).Conclusions Endoscopic PLRA surgery for maxillary sinus IP can reduce peroperative bleeding,shorten operative time and hospital stay,alleviate postoperative inflammatory stress responses,improve nasal ventilation function,and reduce the incidence of complications,demonstrating high clinical application value.