microRNA调控卵巢颗粒细胞代谢的研究进展OA
Advances in microRNA Regulating Ovarian Granulosa Cell Metabolism
卵巢颗粒细胞(granulosa cells,GCs)在卵泡发育及卵巢功能的维持中具有关键作用,其功能障碍与动物繁殖障碍密切相关.miRNA作为一类内源性非编码小分子RNA,通过转录后水平调控靶基因的表达,参与调控GCs的多种生物学过程.本文系统阐述了 GCs与卵泡发育之间的生物学联系,重点探讨了 miRNA通过特异性调节GCs代谢(包括糖代谢、脂代谢及生物氧化)影响卵泡发育的分子机制.通过整合相关研究进展,旨在揭示miRNA在GCs代谢调控中的功能,为提高动物繁殖性能提供理论依据.
Ovarian granulosa cells(GCs)play a critical role in follicular development and the maintenance of ovarian function.Dysfunction of GCs is closely associated with reproductive disorders in animals.As a class of endogenous non-coding small RNAs,miRNAs regulate the expression of target genes at the post-transcriptional level and participate in various biological processes of GCs.This article systematically elucidates the biological relationship between GCs and follicular development,with a focus on the molecular mechanisms by which miRNAs influence follicular development through the specific regulation of GC metabolism,including glucose metabolism,lipid metabolism,and biological oxidation.By integrating relevant research advances,this review aims to reveal the functions of miRNAs in the metabolic regulation of GCs and provide a theoretical basis for improving animal reproduction.
辛琪;张姣姣;王莹
西南大学动物医学院 重庆市牧草与草食家畜重点实验室,重庆 400715西南大学动物医学院 重庆市牧草与草食家畜重点实验室,重庆 400715西南大学动物医学院 重庆市牧草与草食家畜重点实验室,重庆 400715
农业科技
卵巢颗粒细胞miRNA卵泡发育细胞代谢
ovarian granulosa cellsmiRNAfollicular developmentcell metabolism
《畜牧兽医学报》 2026 (8)
4118-4128,11
重庆市自然科学基金(CSTB2025NSCQ-GPX0493)中央高校基本科研业务费专项资金(SWU-KQ24020)
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