驱动蛋白KIF18B在肿瘤与女性生殖中的研究进展OA

Kinesin family member 18B(KIF18B)is a crucial regulator of microtubule dynamics and chromosome segregation.It ensures accurate chromosome alignment during mitosis and plays an essential role in maintaining genomic integrity.In recent years,KIF18B has attracted extensive attention in the research of tumorigenesis and female fertility preservation.In tumors,KIF18B overexpression drives tumorigenesis and progression by inducing chromosomal instability and regulating key signaling pathways.In the field of reproductive health,aberrant KIF18B function is closely linked to declined oocyte quality,diminished ovarian reserve and decreased endometrial receptivity,which directly impairs female fertility.This review comprehensively outlines the molecular regulatory mechanisms of KIF18B,focusing on its roles in cancer and female reproductive function,and related translational research progress,and further discusses its potential as a bridging node between oncology and reproductive medicine,as well as future research perspectives.