基于脑肠轴探讨色氨酸-犬尿氨酸代谢在焦虑障碍中的作用及与肝脾同调的相关性OA

Anxiety disorder is a common mental disease characterized by excessive worry and somatic symptoms.Its pathogenesis is complex,the global incidence is increasing year by year,and the cure rate is low.In recent years,the rise of brain-gut axis theory provides a new perspective for its research.Tryptophan-kynurenine metabolic pathway is a key link in the regulation of brain-gut axis,and its imbalance is related to neurotransmitter disorder,inflammatory response and intestinal flora imbalance,which affects the occurrence and development of anxiety disorder through multiple ways.Traditional Chinese medicine believes that the loss of liver and spleen is the basic pathogenesis of anxiety disorder.Mod-ern studies have found that the imbalance of liver and spleen can activate the hypothalamic-pituitary-adrenal axis and regulate the intestinal flora,which coincide with the pathogenesis of anxiety disorder under the theory of brain-gut axis.This article systematically elaborates the mechanism of tryptophan-kynurenine metabolic pathway under the regulation of brain-gut axis in anxiety disorder,and its correlation with the theory of liver-spleen coherence in traditional Chinese med-icine,in order to provide new ideas for the intervention of anxiety disorder.