益气芪药汤加减联合常规西药治疗2型糖尿病气阴两虚型患者的临床观察OA
Clinical Study of Modified Yiqi Qiyao Decoction Combined with Conventional Western Medicine for Type 2 Diabetes Mellitus with Deficiency of Both Qi and Yin Syndrome
目的 观察益气芪药汤加减对2型糖尿病(type 2 diabetes mellitus,T2DM)气阴两虚型患者胰岛功能及炎症因子的影响.方法 选取2023年2月—2024年7月于烟台市中医医院就诊的80 例T2DM气阴两虚型患者,采用随机数表法分对照组和治疗组,每组40 例;对照组采用常规西药治疗,治疗组在对照组基础上给予益气芪药汤加减治疗,两组患者均治疗4周.观察比较两组患者临床疗效及不良反应情况,比较治疗前后中医证候积分、血糖指标[空腹血糖(fasting plasma glucose,FPG)、糖化血红蛋白(hemoglobin a1c,HbA1c)、餐后2 h血糖(2-hour postprandial blood glucose,2 h PG)]、胰岛功能指标[C肽(C-peptide,C-P)、空腹胰岛素(fasting insulin,FINS)、胰岛素抵抗指数(homeostatic model assessment of insulin resistance,HOMA-IR)]、炎症因子指标[白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C reactive protein,CRP)]水平.结果 治疗后治疗组临床有效率95.00%(38/40)高于对照组的77.50%(31/40),差异有统计学意义(P<0.05).治疗后两组患者中医证候积分较治疗前降低,差异有统计学意义(P<0.05);且治疗组中医证候积分较对照组明显降低,差异有统计学意义(P<0.05).治疗后两组患者FPG、HbA1c、2h PG水平较治疗前降低,差异有统计学意义(P<0.05);且治疗组FPG、HbA1c、2h PG水平较对照组明显降低,差异有统计学意义(P<0.05).治疗后两组患者FINS、HOMA-IR水平较治疗前降低,C-P水平较治疗前升高,差异有统计学意义(P<0.05);且治疗组FINS、HOMA-IR水平较对照组明显降低,C-P水平较对照组明显升高,差异有统计学意义(P<0.05).治疗后两组患者IL-1β、IL-6、TNF-α、CRP水平较治疗前降低,差异有统计学意义(P<0.05);且治疗组IL-1β、IL-6、TNF-α、CRP水平较对照组明显降低,差异有统计学意义(P<0.05).两组患者不良反应发生情况比较,差异无统计学意义(P>0.05).结论 采用益气芪药汤加减治疗T2DM气阴两虚型患者临床效果确切,可降低中医证候积分,调控血糖水平,改善胰岛功能,降低炎症因子水平,且安全性良好.
Objective To observe the effect of modified Yiqi Qiyao Decoction on pancreatic islet function and inflammatory factors in type 2 diabetes mellitus(T2DM)patients with deficiency of both qi and yin syndrome.Methods Eighty T2DM patients with deficiency of both qi and yin syndrome treated at Yantai Hospital of Traditional Chinese Medicine from February 2023 to July 2024 were selected and divided into a control group or a treatment group by the random number table method,with 40 cases in each group.Both groups received conventional Western medicine treatment,while the treatment group additionally received modified Yiqi Qiyao Decoction.After 4 weeks of treatment,the clinical efficacy and adverse reactions were compared between the two groups.The following parameters were assessed before and after treatment:traditional Chinese medicine(TCM)syndrome scores,blood glucose indicators[fasting plasma glucose(FPG),glycated hemoglobin(HbA1c),and 2-hour postprandial blood glucose(2h PG)],pancreatic islet function indicators[C-peptide(C-P),fasting insulin(FINS)and homeostatic model assessment of insulin resistance(HOMA-IR)],as well as inflammatory factor indicators[interleukin-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and C-reactive protein(CRP)].Results After treatment,the clinical effective rate was 95.00%(38/40)in the treatment group,higher than 77.50%(31/40)in the control group(P<0.05).TCM syndrome scores were decreased in both groups(P<0.05),and were significantly lower in the treatment group(P<0.05).FPG,HbA1c,and 2h PG levels were decreased in both groups(P<0.05),and were significantly lower in the treatment group(P<0.05).FINS and HOMA-IR levels were decreased,while the C-P level was increased in both groups(P<0.05),and these changes were more significant in the treatment group(P<0.05).IL-1β,IL-6,TNF-α,and CRP levels were decreased in both groups(P<0.05),and were significantly lower in the treatment group(P<0.05).No statistically significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).Conclusion For T2DM patients with deficiency of both qi and yin syndrome,modified Yiqi Qiyao Decoction exhibits definite therapeutic efficacy.It can reduce TCM syndrome scores,regulate blood glucose levels,improve pancreatic islet function,and decrease inflammatory factor levels,with a favorable safety profile.
邴蕾蕾;蔄婷婷;于春霞;刘伟超
烟台市中医医院,山东 烟台 260014烟台市中医医院,山东 烟台 260014烟台市中医医院,山东 烟台 260014烟台市中医医院,山东 烟台 260014
医药卫生
2型糖尿病气阴两虚型益气芪药汤加减胰岛功能炎症因子
type 2 diabetes mellitusdeficiency of both qi and yin syndromemodified Yiqi Qiyao Decoctionpancreatic islet functioninflammatory factor
《世界中西医结合杂志》 2026 (7)
1370-1374,5
山东省中医药科技项目(M-2022042)
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