当归芍药散对肾病综合征血瘀型患儿疗效及血管内皮功能保护作用观察OA
Observation on the Curative Effect of Danggui Shaoyao Powder(当归芍药散)and Its Protective Effect on Vascular Endothelial Function in Children with Blood Stasis Type Nephrotic Syndrome
目的 探讨当归芍药散治疗肾病综合征血瘀型患儿的临床疗效及其对血管内皮功能的保护作用.方法 选取2025年4月—2025年12月黑龙江省中医医院儿科病房66例肾病综合征血瘀型患儿,随机分为观察组和对照组各33例.对照组采用一般治疗+激素+中成药(槐杞黄颗粒)方案,观察组采用一般治疗+激素+当归芍药散方案,均治疗4周.观察并对比两组患儿治疗前后中医证候积分、尿蛋白转阴时间,以及血管内皮损伤相关指标[血管内皮生长因子(vascular endothelial growth factor,VEGF)、可溶性血管内皮生长因子受体-2(soluble vascular endothelial growth factor receptor 2,sVEGFR2)、内皮素-1(endothelin-1,ET-1)、血小板活化因子(platelet-activating factor,PAF)、总蛋白S(total protein S,TPS)、游离蛋白S(free protein S,FPS)]的水平变化.结果 两组患儿治疗前中医主症积分、次症积分、总积分及各项血管内皮损伤相关指标水平比较差异均无统计学意义(P>0.05).与治疗前比较,治疗后两组上述证候积分均显著降低(P<0.05),且观察组低于对照组(P<0.05);观察组尿蛋白转阴时间[(7.33±1.49)d]显著短于对照组[(10.52±1.60)d](P<0.05);除对照组PAF外,两组其余血管内皮损伤相关指标水平均较治疗前改善(P<0.05),且观察组VEGF、ET-1、PAF下降幅度及sVEGFR2、TPS、FPS升高幅度均显著优于对照组(P<0.05).结论 当归芍药散联合激素治疗肾病综合征血瘀型患儿,可显著改善中医证候,缩短尿蛋白转阴时间,有效保护血管内皮功能.
Objective To investigate the clinical efficacy of Danggui Shaoyao Powder(当归芍药散)in the treatment of children with blood stasis type nephrotic syndrome and its protective effect on the children's vascular endothelial function.Methods A total of 66 children with blood stasis type nephrotic syndrome admitted to the pediatric ward of Heilongjiang provincial hospital of traditional Chinese medicine from April 2025 to December 2025 were selected and randomly divided into an observation group and a control group,with 33 cases in each group.The control group was treated with the regimen of conventional therapy+hormone+Chinese patent drugs[Huaiqihuang Granules(槐杞黄颗粒)],while the observation group was administered the regimen of conventional therapy+hormone+Danggui Shaoyao Powder,with a 4-week treatment course for both groups.The changes in TCM syndrome scores,urine protein negative conversion time,and vascular endothelial injury-related indicators(VEGF,sVEGFR2,ET-1,PAF,TPS,FPS)of the two groups before and after treatment were observed and compared.Results There were no statistically significant differences in TCM primary syndrome scores,secondary syndrome scores,total scores and all vascular endothelial injury-related indicators between the two groups before treatment(P>0.05).After treatment,the above-mentioned syndrome scores of both groups decreased significantly(P<0.05),and those of the observation group were lower than those of the control group(P<0.05).The urine protein negative conversion time of the observation group was(7.33±1.49)days,which was significantly shorter than(10.52±1.60)days of the control group(P<0.05).After treatment,all vascular endothelial injury-related indicators of both groups were improved compared with those before treatment except for PAF in the control group(P<0.05).Moreover,the reduction ranges of VEGF,ET-1 and PAF and the increase ranges of sVEGFR2,TPS and FPS in the observation group were significantly better than those in the control group(P<0.05).Conclusion Danggui Shaoyao Powder combined with hormone in the treatment of children with blood stasis type nephrotic syndrome can significantly improve TCM syndromes,shorten the urine protein negative conversion time and effectively protect vascular endothelial function.
秦曼;张天照
黑龙江省中医药科学院,黑龙江省中医医院,黑龙江 哈尔滨 150036黑龙江省中医药科学院,黑龙江省中医医院,黑龙江 哈尔滨 150036
医药卫生
当归芍药散肾病综合征血瘀型血管内皮功能
Danggui Shaoyao Powder(当归芍药散)nephrotic syndromeblood stasis typevascular endothelial function
《辽宁中医药大学学报》 2026 (9)
5-9,5
黑龙江省自然科学基金项目(PL2024H249)黑龙江省中医药管理局中医药科研课题项目(ZHY2025-091)
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