创伤性脑损伤的治疗研究进展OA
Research Advances in the Treatment of Traumatic Brain Injury
创伤性脑损伤(traumatic brain injury,TBI)是高死亡率、高致残率的重大脑疾病.TBI所致的继发性脑损伤一直缺乏有效的治疗方案,是亟待突破的医学难题.目前已有大量关于TBI治疗的研究报道和新治疗思路出现,但是均未成功转化为临床治疗,TBI继发性脑损伤的临床治疗仍然有待突破.本文主要讨论了 TBI的诊疗现状、治疗研究进展和临床转化困境,旨在为促进TBI的治疗研究提供参考.
Traumatic brain injury(TBI)is a major brain disorder characterized by high mortality and high disability rates.The secondary brain injury caused by TBI has long lacked effective treatment strategies,representing a critical medical challenge that urgently needs to be overcome.Although a substantial amount of research on TBI treatment has been reported and novel therapeutic concepts have emerged,they have not been successfully translated into clinical practice.Therefore,clinical treatment for TBI-induced secondary brain injury remains an area awaiting breakthroughs.This article primarily discusses the current status of TBI diagnosis and treatment,advances in therapeutic research,and the challenges regarding clinical translation,aiming to provide a reference for promoting research into TBI treatment.
鞠聆馨;宋明柯
上海交通大学医学院2021级临床医学八年制一大班 上海 200025上海交通大学基础医学院药理学与化学生物学系 上海 200025
医药卫生
创伤性脑损伤继发性脑损伤药物治疗神经调控干细胞治疗
traumatic brain injury(TBI)secondary brain injurypharmacotherapyneuromodulationstem cell-based therapy
《神经损伤与功能重建》 2026 (8)
480-483,492,5
上海市高水平地方高校"中西医结合研究平台"建设项目(从天然产物虚拟筛选的AEP抑制剂对小胶质细胞炎症的调治作用研究,No.ZXY25005)上海交通大学医学院第十八期大学生创新训练计划项目(他汀类药物对创伤性脑损伤中AEP的抑制作用研究,No.1824058S,No.S202510248430)
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