针灸在膝关节骨性关节炎治疗中作用并对关节功能及血清炎症因子IL-1β、TNF-α、hs-CRP的影响OA
Effect of Acupuncture and Moxibustion in Treatment of Knee Osteoarthritis and Its Effect on Joint Function and Serum Inflammatory Factors IL-1β,TNF-α and hs-CRP
目的 研究针灸辅助治疗膝关节骨性关节炎对关节功能及血清炎症因子白介素-1β(Interleukin-1β,IL-1β)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、超敏 C 反应蛋白(Hypersensitive C-reactive protein,hs-CRP)的影响.方法 选取2022年3月—2024年3月于医院治疗的膝关节骨性关节炎患者102例进行研究,按照入院顺序奇、偶数分成观察组和对照组.对照组51例采用常规西药治疗,观察组51例在对照组基础上增加针灸辅助治疗,疗程4周.比较两组患者的治疗总有效率、中医证候积分、膝关节功能、炎症因子及治疗安全性情况.结果 观察组总有效率98.04％(50/51)、对照组84.31％(43/51),观察组高于对照组(P＜0.05).治疗后,观察组关节疼痛、腰膝酸软、屈伸不利证候积分显著低于对照组[(2.13±0.44)、(2.07±0.45)、(1.74±0.50)分 vs(2.72±0.51)、(2.30±0.38)、(1.98±0.26)分],观察组Lysholm膝关节功能量表(Lysholmknee scale,LKS)评分高于对照组[(87.25±9.03)分vs(82.30±7.56)分],观察组血清炎症因子 IL-1β、TNF-α、hs-CRP 显著低于对照组[(17.25±3.68)pg/mL、(21.04±6.30)pg/mL、(8.12±1.43)μg/mL vs(21.38±3.40)pg/mL、(24.60±5.71)pg/mL、(9.27±1.18)μg/mL](P＜0.05).两组均无严重不良反应发生.结论 针灸辅助治疗膝关节骨性关节炎能够获得更佳疗效,其可以更好地缓解患者中医证候,改善关节功能,并减轻炎症反应,且安全性良好,具有良好的应用价值.
Objective To study the effects of acupuncture and moxibustion on joint function and serum inflammatory factors in-terleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)in adjuvant treatment of knee osteoarthritis.Methods A total of 102 patients with knee osteoarthritis who were treated in the hospital from March 2022 to March 2024 were selected for the study.They were randomly divided into observation group and control group ac-cording to the order of admission,with 51 patients in each group.The patients in the control group were treated with conventional western medicine,and those in the observation group were treated with acupuncture and moxibustion for 4 weeks.The total effec-tive rate,TCM syndrome score,knee joint function,inflammatory factors and treatment safety were compared between the two groups.Results The total effective rate was 98.04％(50/51)in the observation group and 84.31％(43/51)in the control group.The total effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the scores of joint pain,soreness and weakness of waist and knees and unfavorable flexion and extension in the observation group were significantly lower than those in the control group[(2.13±0.44)points,(2.07±0.45)points,(1.74±0.50)points vs(2.72±0.51)points,(2.30±0.38)points,(1.98±0.26)points],the Lysholm knee scale(LKS)score of the observation group was higher than that of the control group[(87.25±9.03)points vs(82.30±7.56)points].The levels of serum inflammatory factors IL-1β,TNF-α and hs-CRP in the observation group were significantly lower than those in the control group[(17.25±3.68)pg/mL,(21.04±6.30)pg/mL,(8.12±1.43)μg/mL vs(21.38±3.40)pg/mL,(24.60±5.71)pg/mL,(9.27±1.18)μg/mL](P＜0.05).No serious adverse reactions occurred in both groups.Conclusion Acupuncture and moxibustion can achieve better curative effect in the treatment of knee osteoarthritis.It can better alleviate the TCM syndromes,improve the joint function and reduce the inflammatory reaction of the patients.It has good safety and good application value.
高国强;崔华峰;冯亚男
济宁医学院附属滕州市中心人民医院,山东滕州 277599山东中医药大学附属医院,山东济南 250014滕州市中医医院,山东滕州 277599
医药卫生
膝关节骨性关节炎骨痹针灸关节功能炎症因子
knee osteoarthritisbone Bi syndromeacupuncturejoint functioninflammatory factors
《中华中医药学刊》 2026 (8)
45-48,4
国家自然科学基金项目(82260757)
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