基于机器学习的中医个体化辨证模式及智慧诊疗模型构建思路OA
Construction Strategy of Machine Learning-Based Individualized Syndrome Differentiation Model and Intelligent Diagnosis-Treatment Framework in Traditional Chinese Medicine
宏观辨证是中医诊疗体系的基础,通过望、闻、问、切四诊方法对患者的整体状态和疾病特征进行整合分析,"以表知里""司外揣内",形成病机的整体认知.微观辨证通过检测患者的组织、细胞、分子和基因水平等微观指标,揭示证候的深层机制与物质基础,是对宏观辨证的补充,也是中医精准化的重要方向.因此,分别从宏观、微观辨证视角,综述了中医证的客观化研究现状,指出通过机器学习建立"宏观-微观"特征关联模式,系统绘制中医"证"的知识图谱,在此基础上序贯采集疾病特征信息,精准把握证候变化及发展趋势,形成临床序贯诊疗辅助决策,是中医走向精准医疗的有效路径.
Macroscopic syndrome differentiation is the foundation of the traditional Chinese medicine(TCM)diagnosis and treatment system.Through the four diagnostic methods of observation,auscultation and olfaction,inquiry and palpation,it in-tegrates and analyzes the overall state of the patient and the characteristics of the disease,"understanding the interior from the ex-terior"and"diagnosing the interior from the exterior",thus forming an overall understanding of the pathogenesis.Microscopic syndrome differentiation,by detecting microscopic indicators such as the tissue,cell,molecular and genetic levels of the patients,revealed the deep mechanism and material basis of syndromes.It is a supplement to macroscopic syndrome differentiation and al-so an important direction for the precision of traditional Chinese medicine.This paper reviewed the current research status of the objectification of TCM syndromes from the perspectives of macro and micro syndrome differentiation respectively.It proposed to establish a"macro-micro"feature correlation model through machine learning,systematically drew the knowledge graph of TCM"syndromes"and on this basis,sequentially collected disease characteristic information,accurately grasped the changes and de-velopment trends of syndromes and form clinical sequential diagnosis and treatment auxiliary decision-making.It is an effective path for traditional Chinese medicine to move towards precision medicine.
屈馨宁;刘宏潇
中国中医科学院广安门医院,北京 100053中国中医科学院广安门医院,北京 100053
医药卫生
机器学习个体化辨证智慧诊疗宏观辨证微观辨证
machine learningindividualized diagnosis and treatmentintelligent diagnosis and treatmentmacroscopic diag-nosis and treatmentmicroscopic diagnosis and treatment
《中华中医药学刊》 2026 (8)
19-22,4
国家自然科学基金面上项目(81873292)中央高水平中医医院临床研究和成果转化能力提升项目(HLCMHPP2023049)北京自然科学基金面上项目(7252264)北京市中医药科技发展资金重点项目(BJZYZD-2023-02)中国中医科学院科技创新工程重点协同攻关项目(CI2023C072YLL)
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