免疫炎症介导肠道菌群膳食与抑郁的关联性研究OA

Objective To investigate the association between the dietary index for gut microbiota(DI-GM)and the risk of depression,and to examine the mediating role of the systemic immune-inflammation index(SII).Methods Data from the National Health and Nutrition Examination Survey 2005 to 2018 were used,comprising 24 370 participants.Depressive status was assessed using the patient health questionnaire-9(PHQ-9).Gut microbiota-related diet quality was evaluated using DI-GM,and immune-inflammatory status was assessed using SII.Survey-weighted linear regression,Logistic regression,restricted cubic spline analysis,and mediation analysis were performed to comprehensively evaluate the associations between DI-GM,SII,and depression.Results Among the participants,6110 individuals exhibited depressive symptoms.After adjustment for multiple confounding factors,DI-GM was negatively associated with PHQ-9 scores and a reduced risk of depression.In contrast,SII was positively associated with PHQ-9 scores and an increased risk of depression.Nonlinear analysis indicated that when ln(SII)≥5.719,the risk of depression increased significantly.Mediation analysis demonstrated that SII partially mediated the association between DI-GM and depression risk,accounting for 3.56%of the total effect.Conclusion Gut microbiota-related diet quality is significantly associated with the risk of depression,and immune-inflammatory responses partially mediate this relationship.These findings suggest that improving dietary patterns and reducing systemic inflammation may help prevent depression.