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基于超声及临床特征的甲状腺滤泡癌预测模型构建OA

Construction of a predictive model for thyroid follicular carcinoma based on ultrasound findings and clinical characteristics

中文摘要英文摘要

目的 探讨基于超声及临床特征的二元多因素Logistic回归分析预测模型对甲状腺滤泡癌(follicular thyroid carcinoma,FTC)的诊断价值.方法 选取2020年4月至2025年8月于福建医科大学附属泉州第一医院行术前超声检查并病理确诊的甲状腺滤泡性肿瘤患者107例作为研究对象,分为甲状腺滤泡性腺瘤组(follicular adenoma,FA)(n=62)与FTC组(n=45),收集并记录患者的临床及超声特征,构建二元多因素Logistic回归分析预测模型,绘制受试者操作特征曲线(receiver operating characteristic curve,ROC曲线),通过计算曲线下面积,对其诊断效能进行评价.结果 二元Logistic回归分析结果表明,两组患者的年龄、甲状腺球蛋白、抗甲状腺球蛋白抗体、超声回声均匀性、声晕完整性、声晕厚度、血流丰富程度比较,差异有统计学意义(P<0.05),上述指标纳入回归分析构建的预测模型ROC曲线下面积为0.936.结论 基于临床特征与超声表现建立的二元多因素 Logistic 回归分析预测模型在甲状腺滤泡性肿瘤良恶性诊断及鉴别诊断中具有重要作用,表现出优异的诊断效能.

Objective To explore the diagnostic value of binary multivariate Logistic regression analysis prediction model based on ultrasound and clinical features in follicular thyroid carcinoma(FTC).Methods A total of 107 patients with thyroid follicular tumors who underwent preoperative ultrasound examination and pathological diagnosis at Quanzhou First Hospital Affiliated to Fujian Medical University from April 2020 to August 2025 were collected as subjects,they were divided into follicular adenoma(FA)group(n=62)and FTC group(n=45).The clinical and ultrasonic characteristics of the patients were collected and recorded,and the binary multivariate Logistic regression analysis prediction model was constructed.The receiver operating characteristic(ROC)curve was drawn,and the diagnostic efficacy was evaluated by calculating the area under the curve.Results Binary Logistic regression analysis showed that age,thyroglobulin,anti-thyroglobulin antibody,echo uniformity,halo integrity,halo thickness,and blood flow richness were statistically different between two groups(P<0.05).The above indicators were included in the regression analysis prediction model.The area under the ROC curve of the prediction model was 0.936.Conclusion The binary multivariate Logistic regression analysis prediction model based on clinical features and ultrasound findings showed good diagnostic efficacy in the diagnosis and differential diagnosis of benign and malignant thyroid follicular tumors.

颜小斌;谢思培;谢巧捷

福建医科大学附属泉州第一医院超声科,福建 泉州 362000福建医科大学附属泉州第一医院超声科,福建 泉州 362000福建医科大学附属泉州第一医院超声科,福建 泉州 362000

医药卫生

甲状腺滤泡癌超声预测模型临床指标

Thyroid follicular carcinomaUltrasoundPrediction modelClinical indicators

《中国现代医生》 2026 (20)

35-38,4

10.3969/j.issn.1673-9701.2026.20.009

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