孕晚期血脂异常对子代6~8岁儿童肥胖的预测价值研究OA

Objective To investigate the association between maternal dyslipidemia late pregnancy and obesity in offspring aged 6-8 years.Methods A total of 808 pregnant women admitted to Ningbo University Affiliated Women and Children's Hospital from January 2014 to December 2016 were enrolled as study subjects.They were divided into abnormal lipid profile group(n=417)and normal lipid profile group(n=391)based on the presence or absence of dyslipidemia during late pregnancy.Laboratory data including prepartum fasting serum levels of total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)were collected.Information on offspring height and body weight was obtained through telephone follow-up.Univariate analysis and binary Logistic regression analysis were employed to identify factors influencing obesity,while the receiver operating characteristic(ROC)curve was used to evaluate predictive performance.Results Abnormal levels of TC and LDL-C during late pregnancy were associated with a higher incidence of offspring obesity compared to normal pregnancies(P<0.05).Bivariate Logistic regression analysis demonstrated that TC and LDL-C were independent risk factors for offspring obesity.ROC curve analysis revealed that the area under the curve for LDL-C,TC,and their combination were 0.595,0.648,and 0.656,respectively.The maximum Jordon index predicted by the combined model of TC and LDL-C was 0.068.Conclusion Elevated levels of TC and LDL-C in late pregnancy are associated with obesity in offspring aged 6-8 years,particularly demonstrating potential stratified screening significance in terms of high negative predictive value.