有毒中药抗肿瘤的毒性调控:"有故无殒"理论与现代分析技术的协同研究OA

The global burden of cancer continues to escalate.Although traditional Chinese medicine(TCM)has demon-strated unique efficacy in oncology,the inappropriate use of toxic Chinese medicines occurs occasionally,compromising their clinical application.This article explores the safe and rational use of toxic Chinese medicines in cancer treatment based on the"You Gu Wu Yun"theory.Originating from the Huang Di Nei Jing(The Yellow Emperor's Inner Classic),this theory was initially articulated in the context of medication use during pregnancy.Its core principle,"you bing bing shou zhi"(meaning the disease bears the brunt of the drug's impact),has evolved into a clinical medication principle through the continuous practice of later generations of physicians.Based on this theory,when toxic Chinese medicines are used in antitumor therapy,they should be applied according to the following principles:"fighting poison with poison","cor-recting imbalances with potent agents",differentiating syndromes while reinforcing the middle energizer,and discontinuing medication once the therapeutic effect is achieved.Advances in modern analytical techniques have provided technical sup-port for studies such as quantitative toxicology of Chinese medicine and functional metabolomics,thereby offering new in-sights and methods for deepening the understanding of the antitumor mechanisms of toxic Chinese medicines,as well as their clinical application and safety evaluation.