不同深度电针夹脊穴治疗非酒精性脂肪性肝病的疗效观察OA

Objective:To compare the therapeutic efficacy of electroacupuncture at Jiaji(EX-B2)points with different needling depths in treating non-alcoholic fatty liver disease(NAFLD). Methods:Seventy-two patients with NAFLD were randomly allocated to an observation group and a control group using a random number table,with 36 cases per group.Both groups received basic intervention.In addition,the observation group received perpendicular needling at Jiaji(EX-B2)points from T7 to T10 with a penetration depth of 1.5 Cun,and the control group received penetrating needling at the same points but with a penetration depth of 0.5 Cun;needles at the T7 and T10 Jiaji(EX-B2)points were connected to electroacupuncture ipsilaterally,with a sparse-dense wave and a frequency of 2 Hz/100 Hz.The needles were retained for 30 min per session,and the treatment was offered once every other day,3 times weekly,followed by 1 d of rest,for a total of 8 weeks.Clinical efficacy was compared between the two groups at the end of treatment;ultrasonographic features of the liver,traditional Chinese medicine(TCM)symptom score,and serum liver function enzymes and lipid metabolism parameters were assessed among participants. Results:During the study,2 participants dropped out of the observation group and 3 from the control group.The effective rate was 88.2%in the observation group based on the hepatic ultrasonographic grading,higher than 57.6%in the control group(P<0.01).The ultrasonographic grading of the liver showed that the observation group improved fatty liver grade more than the control group(P<0.05).Regarding the TCM symptom score,the observation group showed a greater reduction than the control group(P<0.01).In terms of serum liver function enzymes,the levels of alanine transaminase(ALT)and aspartate transaminase(AST)decreased more significantly in the observation group than in the control group(P<0.05);there was no significant difference in the level of γ-glutamyl transferase(GGT)between the two groups(P>0.05).Regarding the lipid metabolism parameters,the observation group was superior to the control group in reducing the levels of serum total cholesterol(TC),triglyceride(TG),and low-density lipoprotein cholesterol(LDL-C)(P<0.05),while the difference was not significant in elevating the level of serum high-density lipoprotein cholesterol(HDL-C)(P>0.05). Conclusion:Electroacupuncture at Jiaji(EX-B2)points can improve hepatic ultrasonographic grading and serum liver function enzymes and lipid metabolism parameters.The depth of needling affects therapeutic efficacy;deep needling outperforms shallow needling in improving hepatic ultrasonographic grading and decreasing the TCM symptom score and serum liver function enzymes(AST and ALT)and lipid metabolism parameters(TC,TG,and LDL-C),while their effects on reducing GGT and elevating HDL-C levels are equivalent.