糖尿病前期人群中国内脏脂肪指数与缺血性卒中复发风险的关联性研究OA

Objective To investigate the association between Chinese visceral adiposity index(CVAI)and the risk of recurrent ischemic stroke(IS)in individuals with prediabetes. Methods The study enrolled individuals with prediabetes who had suffered from first-ever IS and had CVAI data from China national stroke registry Ⅲ(CNSR-Ⅲ).The calculation formula of CVAI for males was defined as follows:CVAI=-267.93+0.68×age(years)+0.03×BMI(kg/m2)+4.00×waist circumference(cm)+22.00×lg[TG(mmol/L)]-16.32×HDL-C(mmol/L).For females,the formula was CVAI=-187.32+1.71×age(years)+4.32×BMI(kg/m2)+1.12×waist circumference(cm)+39.76×lg[TG(mmol/L)]-11.66×HDL-C(mmol/L).The Cox proportional hazards model was applied to evaluate the association between CVAI and the risk of recurrent IS. Results A total of 2599 individuals with prediabetes who had suffered from first-ever IS and with complete CVAI data were included.Multivariate Cox regression analysis demonstrated that elevated CVAI levels were associated with an increased risk of 3-month recurrent IS.In comparison with the lowest CVAI tertile group,the highest tertile group had a HR of 1.72(95%CI 1.08-2.73). Conclusions Elevated CVAI levels are associated with increased 3-month recurrent IS risk in individuals with prediabetes,suggesting CVAI may serve as a supplementary tool for risk assessment.