迷走神经刺激治疗卒中:机制与进展OA

As a non-pharmacological neuromodulation strategy,vagus nerve stimulation(VNS)has attracted extensive attention in the field of stroke therapy in recent years.VNS can ameliorate neurological dysfunction after stroke by enhancing neuroplasticity,regulating inflammatory responses,promoting vascular repair,improving cerebral blood flow and metabolic homeostasis,as well as modulating excitotoxicity,oxidative stress,apoptosis,autophagy,and other biological processes.Preclinical studies have demonstrated that both invasive and non-invasive VNS can alleviate stroke-related brain injury and promote the recovery of motor function.Clinical trials have further indicated that VNS is associated with the improvement of motor,cognitive and sensory functions in both acute and chronic stages of stroke,and has potential benefits for complications such as post-stroke dysphagia and post-stroke depression,with favorable safety and tolerability profiles.Future research should focus on the optimization of stimulation parameters,individualized strategies and multimodal combination to improve the predictability of VNS efficacy and expand its clinical applications.