加味葛根芩连汤联合针刺治疗溃疡性结肠炎(大肠湿热证)患者的临床效果OA
Clinical Efficacy of Modified Gegen Qinlian Decoction Combined with Acupuncture in the Treatment of Patients with Ulcerative Colitis(Damp-Heat in Large Intestine Syndrome)
目的:观察加味葛根芩连汤联合针刺治疗溃疡性结肠炎(UC)(大肠湿热证)患者的临床效果.方法:回顾性分析 2022 年 5 月—2025 年 6 月松滋市中医医院 110 例UC(大肠湿热证)患者的临床资料,根据治疗方法不同分为A组、B组,各 55 例,B组给予双歧杆菌三联活菌胶囊及美沙拉秦缓释颗粒治疗,A组在B组基础上加用加味葛根芩连汤联合针刺治疗.对比两组临床疗效、症状改善时间、疾病活动度、炎症指标、肝功能蛋白水平及不良反应发生率.结果:治疗4周后,A组总有效率高于B组(P<0.05).A组总有效者腹泻、腹痛及黏液脓血便消失时间早于B组总有效者(P<0.05).治疗 4 周后,A组疾病活动指数(DAI)评分低于B组(P<0.05).治疗 4 周后,A组WBC、CRP、红细胞沉降率(ESR)低于B组(P<0.05).两组治疗 4 周后总蛋白(TP)、白蛋白(ALB)比较,差异无统计学意义(P>0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:在常规西医治疗基础上加用加味葛根芩连汤联合针刺辅助治疗UC(大肠湿热证),能显著提高临床疗效,缩短症状缓解时间,降低肠道炎症及疾病活动度,且对肝脏合成功能无明显影响.
Objective:To observe the clinical efficacy of modified Gegen Qinlian Decoction combined with acupuncture in the treatment of ulcerative colitis(UC)(damp-heat in large intestine syndrome).Method:The clinical data of 110 patients with UC(damp-heat in large intestine syndrome)treated at Songzi City Hospital of Traditional Chinese Medicine from May 2022 to June 2025 were retrospectively analyzed.According to different treatment methods,the patients were divided into group A and group B,with 55 cases in each group.Group B was treated with Bifidobacterium Triple Viable Capsules and Mesalazine Sustained-release Granules,while group A was additionally treated with modified Gegen Qinlian Decoction combined with acupuncture on the basis of the treatment in group B.The clinical efficacy,symptom improvement time,disease activity,inflammatory indicators,liver function protein levels,and incidence of adverse reactions were compared between the two groups.Result:After 4 weeks of treatment,the total effective rate in group A was higher than that in group B(P<0.05).The disappearance time of diarrhea,abdominal pain,and mucopurulent bloody stool in total effective patients of group A were earlier than those in total effective patients of group B(P<0.05).After 4 weeks of treatment,the disease activity index(DAI)score in group A was lower than that in group B(P<0.05).After 4 weeks of treatment,the levels of WBC,CRP and erythrocyte sedimentation rate(ESR)in group A were lower than those in group B(P<0.05).After 4 weeks of treatment,there were no statistically significant differences in total protein(TP)and albumin(ALB)levels between the two groups(P>0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:On the basis of conventional western medicine treatment,adjuvant therapy with modified Gegen Qinlian Decoction combined with acupuncture for UC(damp-heat in large intestine syndrome)can significantly improve clinical efficacy,shorten symptom remission time,reduce intestinal inflammation and disease activity,and has no significant impact on liver synthetic function.
梅宝龙;张杰;邓滟娇
松滋市中医医院脾胃病科 湖北 松滋 434200松滋市中医医院心脑病科 湖北 松滋 434200松滋市中医医院中医治疗室 湖北 松滋 434200
医药卫生
加味葛根芩连汤针刺溃疡性结肠炎炎症因子疾病活动度
Modified Gegen Qinlian DecoctionAcupunctureUlcerative colitisInflammatory factorsDisease activity
《中国医学创新》 2026 (21)
46-50,5
荆州市科技计划项目(2024HD203)
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