水飞蓟宾联合五禽戏锻炼治疗非酒精性脂肪性肝炎的效果OA
Efficacy of Silibinin Combined with Wuqinxi Exercise in the Treatment of Non-alcoholic Steatohepatitis
目的:探讨水飞蓟宾联合五禽戏锻炼对非酒精性脂肪性肝炎患者临床指标的影响.方法:回顾性选取 2024 年 1 月—2025 年 2 月九江市第一人民医院肝病科收治的 102 例非酒精性脂肪性肝炎患者,根据不同治疗方案分为研究组(采用水飞蓟宾胶囊联合五禽戏锻炼)和对照组(采用水飞蓟宾胶囊单药治疗),每组 51 例.治疗周期为 12 周.检测两组治疗前后肝功能指标(丙氨酸氨基转移酶、天冬氨酸氨基转移酶)、肝/肾回声对比度、肝衰减系数、血脂谱(甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)、肝纤维化标志物(透明质酸、层粘连蛋白、Ⅲ型前胶原、Ⅳ型胶原、基质金属蛋白酶抑制剂 1)、胰岛素抵抗指数、炎症因子(白细胞介素-6、肿瘤坏死因子-α)、免疫指标(自然杀伤细胞活性)及临床疗效.结果:治疗后,研究组丙氨酸氨基转移酶、天冬氨酸氨基转移酶、肝/肾回声对比度、肝衰减系数、甘油三酯、胰岛素抵抗指数、白细胞介素-6、肿瘤坏死因子-α、透明质酸、层粘连蛋白、Ⅲ型前胶原、Ⅳ型胶原、基质金属蛋白酶抑制剂 1 均低于对照组,而高密度脂蛋白胆固醇和自然杀伤细胞活性高于对照组(P<0.05).研究组临床总有效率高于对照组(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:水飞蓟宾联合五禽戏锻炼可有效改善非酒精性脂肪性肝炎患者的肝功能和肝纤维化状态,提升治疗效果,且安全性良好.
Objective:To explore the effect of Silibinin combined with Wuqinxi exercise on the clinical indicators of patients with non-alcoholic steatohepatitis.Method:A total of 102 patients with non-alcoholic steatohepatitis admitted to the Department of Liver Disease of Jiujiang NO.1 People's Hospital from January 2024 to February 2025 were retrospectively selected and divided into study group(receiving Silibinin Capsules combined with Wuqinxi exercise)and control group(receiving Silibinin Capsules alone)according to different treatment plans,with 51 cases in each group.The treatment lasted for 12 weeks.The liver function indicators(alanine aminotransferase,aspartate aminotransferase),liver/kidney echo contrast,liver attenuation coefficient,lipid profile(triglycerides,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol),liver fibrosis markers(hyaluronic acid,laminin,procollagen Ⅲ peptide,collagen Ⅳ,tissue inhibitor of metalloproteinase-1),homeostasis model assessment of insulin resistance,inflammatory factors(interleukin-6,tumor necrosis factor-α),immune indicators(natural killer cell activity)before and after the treatment and clinical efficacy of the two groups were detected.Result:After the treatment,the levels of alanine aminotransferase,aspartate aminotransferase,liver/kidney echo contrast,liver attenuation coefficient,triglycerides,Homeostasis model assessment of insulin resistance,interleukin-6,tumor necrosis factor-α,hyaluronic acid,laminin,procollagen Ⅲ peptide,collagen Ⅳ,tissue inhibitor of metalloproteinase-1 in the study group were all lower than those in the control group,however,the high-density lipoprotein cholesterol and natural killer cell activity were higher than those of the control group(P<0.05).The total clinical effective rate of the study group was higher than that of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Silibinin combined with Wuqinxi exercise can effectively improve the liver function and liver fibrosis status of patients with non-alcoholic steatohepatitis,enhance the therapeutic effect,and has good safety.
许海波;石磬;张宇;刘泉华;江罗佳
九江市第一人民医院肝病科 江西 九江 332000九江市第一人民医院肝病科 江西 九江 332000九江市第一人民医院肝病科 江西 九江 332000九江市第一人民医院麻醉科 江西 九江 332000九江市第一人民医院肾内科 江西 九江 332000
医药卫生
非酒精性脂肪性肝炎水飞蓟宾五禽戏肝功能肝纤维化
Non-alcoholic steatohepatitisSilibininWuqinxiLiver functionLiver fibrosis
《中国医学创新》 2026 (19)
5-9,5
江西省中医药管理局科技计划项目(2023B0741)
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