肺癌NDRG2表达与微卫星不稳定性及预后的关系OA

Objective To investigate the correlation of the expression of N-myc downstream-regulated gene 2(NDRG2)with micro-satellite instability and prognosis in patients with lung cancer.Methods A total of 300 patients who underwent radical resection for lung cancer at the 908th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army between June 2018 and December 2023 were selected.Based on their postoperative prognoses,the patients were divided into poor and good prognosis groups.Pearson correlation analysis was used to investigate the correlation between NDRG2 expression in lung cancer tissues and microsatellite instability,and logistic regression analysis was performed to identify the risk factors for poor prognosis.Results There were 98 patients(32.67%)in the poor prognosis group and 202(67.33%)in the good prognosis group.Correlation analysis showed that negative expression NDRG2 in lung cancer tissues was positively correlated with microsatellite instability-low(MSI-L)or microsatellite stable(MSS)(r=0.694,P<0.001).Multivariate analysis revealed that age,degree of differentiation,TNM stage,vascular invasion,NDRG2,and microsatellite instability were independent factors influencing poor prognosis in patients with lung cancer.The area under the receiver operating charac-teristic(ROC)curve was 0.760(95%CI:0.622-0.807),with a sensitivity of 62.2%,specificity of 80.7%,and Youden index of 0.429.The Hosmer-Lemeshow test showed that the model fits well(χ2=10.117,P>0.05).Conclusion NDRG2 expression in lung cancer patients is positively correlated with microsatellite instability types of MSI-L or MSS and has a certain predictive value for poor prognosis.