肝硬化并发重度GOV型食管胃静脉曲张内镜下不同治疗方式疗效评价OA

Objective Comparing the clinical efficacy of different endoscopic treatment modalities for severe GOV type esophagogastric varices in cirrhosis.Methods Retrospective analysis of the clinical data of 159 patients with severe GOV varicose veins in liver cirrhosis admitted to the department of gastroenterology of the Affiliated Hospital of Yan'an University from Jan.2018 to Dec.2023.Based on the endoscopic treatment modality,they were divided into group A(n=33),group B(n=70),and group C(n=56).Group A was the simple ligation group,group B was the tissue adhesive combined ligation group,and group C was the tissue adhesive combined sclerotherapy group.The three groups of patients were compared in terms of apparent efficiency of the first treatment,complications,laboratory and imaging indexes before and after treatment,the cumulative number of treatments at the time of complete elimination of varicose veins,recurrence rate and recurrence time.Results Comparison of the apparent efficiency of the first treatment showed that Group B(84.3％)and Group C(85.7％)were significantly higher than Group A(60.6％),with statistically significant differences(P＜0.016);comparison of complications one month after the first treatment showed no statistically significant differences among the three groups(P＞0.05);the cumulative number of treatments was higher in Group A[4(3,5)]than in Groups B[3(2,4)]and C[3(3,4)],with statistically significant differences(P＜0.05);there were no statistically significant differences in recurrence rates among the three groups(P＞0.05);comparison of recurrence time showed that Group A[(14.50±2.35)months]was shorter than Groups B[(18.00±1.87)months]and C[(16.60±1.65)months],with statistically significant differences(P＜0.05);there were no statistically significant differences between Groups B and C in terms of the apparent efficiency of the first treatment,cumulative number of treatments,or recurrence time(P＞0.05).Conclusion The clinical efficacy of the tissue adhesive combined ligation group and the tissue adhesive combined sclerotherapy group is superior to that of the simple ligation group,as evidenced by an increase in the apparent efficiency of the first treatment,a reduction in the cumulative number of treatments and a significant delay in the time to relapse.