基于中西医临床病证特点的肺纤维化动物模型分析OA

Pulmonary fibrosis(PF)is a chronic progressive interstitial lung disease with a high mortality rate.Its pathogenesis is complex and current therapeutic options are limited.In contrast,Chinese herbal medicine,with the advantages of multi-target mechanisms and a high safety profile,presents a potential complementary strategy for managing this condition.The establishment of appropriate animal models is critical for investigating disease mechanisms and evaluating potential therapeutic interventions.This systematic review considers existing animal models of PF in both traditional Chinese and Western medicines,with an emphasis on their alignment with clinical manifestations.Intratracheal administration of bleomycin is the main method used in Western medicine to induce PF in animal models.Among these,the model induced by repeated bleomycin administration via tracheotomy most closely mimics the characteristics of PF,demonstrating 95％consistency with Western clinical features and 60％consistency with traditional Chinese medicine(TCM)syndrome patterns.In contrast,research on TCM PF-based animal models remains limited,primarily focusing on syndromes such as Qi deficiency with blood stasis and kidney Yang deficiency.A Qi deficiency and blood stasis syndrome model exhibits 60％consistency with Western medicine and 44％consistency with TCM.Overall,Western medicine-based animal models of PF demonstrate relatively high consistency with clinical features,but exhibit limitations in terms of replicating the full spectrum of disease progression,etiological heterogeneity,and early-stage pathological manifestations.Consequently,these models often fail to capture the chronicity and multifactorial complexity characteristic of the human disease.In contrast,the TCM model demonstrates lower fitness and challenges,such as the lack of standardized modeling and evaluation systems,and difficulty in reflecting the core pathogenic concepts of TCM.Furthermore,a modeling approach that prioritizes"disease"over"syndrome"contradicts the holistic perspective of TCM.Constraints significantly limit their translational applicability.It is therefore essential to develop integrated disease-syndrome models and standardized evaluation systems to advance the clinical translation of integrated TCM and Western medicine research.