城市化背景下腹泻型肠易激综合征与代谢综合征的共病机制OA

In an urbanized society,changes in dietary patterns and increased life stress have led to a steady annual rise in the incidence of diarrhea predominant irritable bowel syndrome(IBS-D),substantially impairing patients' quality of life.Concurrently,metabolic disorders such as obesity,diabetes,and metabolic dysfunction-associted steatotic liver disease are also increasing,and multisystem damage associated with metabolic syndrome(MetS)has drawn considerable research attention.Although the independent pathogenesis of each condition is well recognized,the pathological mechanisms and physiological interactions underlying their comorbidity remain unclear.Accordingly,this review uses the brain-gut axis imbalance as a conceptual framework to systematically synthesize and summarize the current evidence on their co-occurrence.In addition,we explore the traditional Chinese medicine theory of"treating different diseases with the same approach"from the perspective that the spleen governs transportation and transformation.This integrative perspective aims to overcome current therapeutic bottleneck in managing IBS-D and MetS comorbidity,optimize clinical management strategies,and offer insights and references for the integration of Chinese and Western medicine.