非侵入性脑刺激技术改善脑卒中后平衡功能的网状Meta分析OA
Non-invasive brain stimulation techniques for balance function after stroke:a network meta-analysis
目的 采用网状Meta分析系统对比不同非侵入性脑刺激(NIBS)技术对脑卒中患者平衡功能的干预疗效. 方法 系统检索PubMed、Embase、Web of Science、Cochrane Library、Scopus、中国知网数据库,检索时限自建库至2026年2月,纳入探究NIBS改善脑卒中平衡功能的随机对照试验(RCT)和随机交叉试验(RCD).采用Cochrane偏倚风险评估工具进行偏倚风险评价;采用RevMan 5.4进行敏感性分析;采用Stata 18.0进行亚组分析和网状Meta分析. 结果 最终纳入35项研究(31项RCT、4项RCD),涉及1 226例患者.网状Meta结果显示,各类NIBS对计时起立行走测试结局无显著改善效应;经颅直流电刺激(tDCS)改善Berg平衡量表疗效排序最优(SUCRA=85.9%).亚组分析提示,病程≤6个月、刺激靶点为初级运动皮质、磁刺激参数80%～100%RMT的干预方案平衡获益更显著. 结论 tDCS改善脑卒中患者综合平衡功能的疗效最优,可作为脑卒中平衡康复的辅助干预手段.
Objective To systematically compare the efficacy of different non-invasive brain stimulation(NIBS)techniques on bal-ance function in stroke patients via network meta-analysis. Methods PubMed,Embase,Web of Science,Cochrane Library,Scopus and CNKI were systematically searched from da-tabase establishment to February,2026.Randomized controlled trials(RCTs)and randomized crossover designs(RCDs)investigating NIBS for post-stroke balance impairment were enrolled.The Cochrane risk of bias assess-ment tool was used for risk-of-bias assessment;RevMan 5.4 was used for sensitivity analysis,and Stata 18.0 for subgroup analysis and network meta-analysis. Results A total of 35 eligible studies(31 RCTs,4 RCDs)involving 1 226 stroke patients were included.No NIBS modal-ities might significantly improve the outcome of Timed Up and Go Test,while the effect of transcranial direct cur-rent stimulation(tDCS)ranked first on Berg Balance Scale score(SUCRA=85.9%).Subgroup analyses indicat-ed superior balance benefits in interventions targeting primary motor cortex,with stimulation intensity of 80%to 100%RMT and disease courses≤6 months. Conclusion tDCS may be an optimal intervention for comprehensive balance function after stroke.
闫嘉铮;罗小琴;刘日华;于瀛;亓丰学
北京体育大学竞技体育学院运动与脑科学实验室,北京市 100084北京体育大学竞技体育学院运动与脑科学实验室,北京市 100084北京体育大学竞技体育学院运动与脑科学实验室,北京市 100084山东大学体育学院,山东 济南市 250100北京体育大学竞技体育学院运动与脑科学实验室,北京市 100084
医药卫生
脑卒中非侵入性脑刺激平衡功能网状Meta分析
strokenon-invasive brain stimulationbalancenetwork meta-analysis
《中国康复理论与实践》 2026 (8)
903-915,13
1.中央高校基本科研业务费专项资金资助课题/运动康复教育部重点实验室(No.2025KYPT12)2.北京体育大学高层次人才科研启动项目(No.3101037) Supported by Fundamental Research Funds for the Central Universities/the Laboratory of Exercise Rehabilitation Science(No.2025KYPT12)and Research Foundation for Advanced Talents of Beijing Sport University(No.3101037)
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