肺腺癌脊柱定向转移的分子机制与精准诊疗研究进展OA

Lung adenocarcinoma(LUAD)is the most common subtype of non-small cell lung cancer(NSCLC),with a high incidence of spinal metastasis and poor prognosis.Spinal metastasis of LUAD is not merely a simple bone metas-tasis but a directed metastasis process mediated by the anatomical characteristics of the spine,microenvironment specificity,and molecular regulatory mechanisms.However,current research mainly focuses on general bone metastasis,and a dedicated mechanism and precise diagnosis and treatment system for spinal-directed metastasis have not yet been established.Therefore,this article systematically elaborates on the molecular mechanisms of LUAD spinal-directed metastasis from three key aspects:metastatic potential,microenvironment regulation,and metastasis pathways.Combined with the clinical characteristics of spi-nal metastasis and the current research deficiencies,it provides new ideas for basic research and clinical precise prevention and treatment of LUAD spinal metastasis.