英文文献中天然黄酮化合物与阿尔茨海默病动物试验的系统评价OA

Objective To summarize the evidence of the effects of natural flavonoids on cognitive function and pathophysiological phenomena in Alzheimer Disease(AD)animal models.Methods Literatures in PubMed,Web of Science and Embase databases were systematically searched.AD animal model studies were included.Cognitive behavioral indicators(such as water maze,Y maze,dark avoidance test),pathological indicators(A β load,tau phosphorylation,neuroinflammation,oxidative stress,etc.)and dosage regimens were extracted.The risk of bias was evaluated by SYRCLE tool,and the results were summarized by narrative comprehensive analysis method.Results A total of 28 animal studies(＞1200 animals)were included.Most flavonoids significantly improved the cognitive function of AD models,reduced Aβ deposition and tau protein phosphorylation levels,and alleviated neuroinflammation and oxidative stress.Among them,luteolin(n=6),nobiletin(n=3),and 7,8-dihydroxyflavone(n=5)had more evidence of action.There were differences in the results of some studies.For example,7,8-dihydroxyflavone was not observed to improve cognitive function in one study,and nobiletin had no significant effect on Aβ deposition in one study.Conclusion Natural flavonoids have definite neuroprotective effects in improving cognitive function,reducing Aβ deposition,inhibiting tau protein phosphorylation,and reducing neuroinflammation and oxidative stress.However,different studies have heterogeneity in animal models,dosage and duration of intervention,and most studies have a high risk of bias.However,standardized long-term high-quality animal and clinical studies are still needed to further verify its efficacy and safety.