玄参-夏枯草药对治疗桥本甲状腺炎作用机制的研究OA

This study aims to explore the mechanism of Scrophularia ningpoensis-Prunella vulgaris herb pair in the treatment of Hashimoto's thyroiditis by network pharmacology and molecular docking.The active ingredient targets and disease targets of Scrophularia Radix and Prunellae Spica were screened in TCMSP,Uniprot,OMIM and GeneCards databases.The'drug-active ingredient-target'(D-A-T)network diagram was drawn,and the core targets in the network were excavated.GO function enrichment analysis and KEGG pathway enrichment analysis were performed on the core targets.Finally,molecular docking was performed to evaluate the predicted interactions between the core components and core targets.It was found that S.ningpoensis and P.vulgaris acted on AKT1,TNF,CASP3,TP53,VEGFA,IL-6 and other core targets through quercetin,β-sitosterol,kaempferol,luteolin,paeoniflorin and other core components,and regulated IL-17,PI3K-Akt,TNF,HIF-1 and other signaling pathways.The molecular docking results showed that the core components and core targets had good binding activity.In this study,network pharmacology and molecular docking techniques were used to reveal that S.ningpoensis and P.vulgaris regulate HT in a multi-component,multi-target and systematic manner,providing a basis for further research.