云木香中倍半萜类成分及其衍生物的结构修饰与药理活性研究进展OA
Research progress on structural modification and pharmacological activities of sesquiterpenoids and their derivatives in Aucklandia lappa Decne.
云木香是我国传统常用中药,具有悠久的使用历史和多种药理活性.近年来,随着对菊科云木香属植物的深入研究,其所含化学成分及其药理作用被不断揭示.本文系统综述了云木香的主要化学成分,包括去氢木香内酯、木香烃内酯等,并进一步总结了这些核心成分的衍生物在结构修饰后的药理研究进展,特别是在抗炎、抗肿瘤及调节胃肠功能等方面的作用机制.旨在为云木香及其活性成分的深入研究与药物开发提供参考依据.
Aucklandia lappa Decne.is a traditional Chinese medicine with a long history of use and multiple pharmacological activities.In recent years,with the in-depth research on Asteraceae plants,the chemical constituents and pharmacological effects of Aucklandia lappa have been continuously revealed.This paper systematically reviews the main chemical components of Aucklandia lappa,including dehydrocostus lactone,costunolide,and so on.It further summarizes the research progress on the pharmacological activities of derivatives of these core components after structural modification,particularly the action mechanisms in anti-inflammation,anti-tumor,and gastrointestinal function regulation.It aims to provide a reference for the in-depth research and drug development of Aucklandia lappa and its active components.
杨恒俐;毛泽伟;李艳平
云南中医药大学 中药学院,云南 昆明 650500云南中医药大学 中药学院,云南 昆明 650500云南中医药大学 中药学院,云南 昆明 650500
医药卫生
云木香木香烃内酯抗炎抗菌结构修饰
Aucklandia lappa Decne.costunolideanti-inflammatoryanti-bacterialstructural modification
《云南民族大学学报(自然科学版)》 2026 (4)
433-449,17
云南省应用基础研究计划项目中医联合专项(202101AZ070001-326)云南省应用基础研究计划(202201AT070228).
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